Tract-Based Spatial Statistics of Diffusion MRI in Paediatric Multiple Sclerosis
نویسندگان
چکیده
Purpose Paediatric onset multiple sclerosis (POMS) is known to result in a slower accumulation of physical disability over time despite the higher relapse rate than adult-onset MS [1]. However, the mechanisms associated with POMS remain unclear. In this study we aim to investigate microstructural differences between paediatric MS patients and healthy control children using tract-space spatial statistics (TBSS) [2]. We present preliminary results showing increased mean diffusivity (MD) and reduced fractional anisotropy (FA), a pattern consistent with severe demyelination, which is widespread across the white matter.
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Differentiation of Pathological Processes and Clinical Forms in Multiple Sclerosis: a Tract Based Spatial Statistics Study
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